Male Infertility Panels

A range of genetic tests can be used to ascertain both quantitatively and qualitatively the nature of sperm integrity.

Needless to say, males share equal responsibility in matters concerning fertility and chances of a successful conception. Here, the genetic factors come into play a great deal. That’s why it is imperative for the individual(s) to get the requisite tests done, that too, in due time so that accurate assessment and management of the genetic problem can be adopted.

DNA Frgmentation index(DFI) – It is a sperm test used to access the fragmentation index. Higher, the rate of fragmentation that can be detected in the sperm, lesser is the possibility of fertilization. And even if it does result in fertilization, chances of abnormalities occurring in the developing embryo/foetus becomes significantly high. Sperm DNA damage is measured by a qualitative assessment. Antioxidants, when given, helps to improve sperm parameters.

Sperm FISH – The measurement of chromosomes in sperm is a quantitative assessment. Even though, the nature of sperm chromatin is haploid, the possibility of some chromosomal aneuploidies in sperms such as nullisomies, diploidies etc cannot be ignored. And in case they are present, it creates abnormal embryos/ foetus after fertilization. The aneuploidies in sperm, when tested help the clinician to understand the fertilization potential occurring due to previous ART Failures and multiple abortions if any. Another advantage of this technique is that it allows the characterization of a part of the spermatozoa’s genetic material and also in knowing the number of chromosome copies in each sperm (percentage of sperm chromosomatically altered aneuploidies). This can be achieved by fluorescent probes for each chromosome.

Indications for FISH:

•    Oligozoospermia
•    Asthenozoospermia
•    Teratozoospermia
•    IVF Failures
•    Recurrent Abortions
•    Advanced Paternal Age

Y Chromosome micro-deletions :

Y chromosome micro-deletion test which covers all the major genes is involved in the process of spermatogenesis.

When this Y chromosome micro-deletion is screened, it aids the clinician in evaluating males with conditions such as Azoospermia (Zero-Sperm), severe Oligozoospermia, or otherwise unexplained male factor infertility.


•    It is in patients undergoing ICSI, TESE and Micro TESE, screening of Y-Chromosome micro-deletions are indicated. It helps to prevent possible risks involved in transmitting Y-Chromosome micro-deletions to the offspring.


One of the major reasons for the recurring pregnancy losses and IVF failures is a disorder occurring in the endometrium which mainly concerns abnormal gene expressions. Now using the procedure Endometrial Receptor Gene Assay (ERGA), it is possible to...

This is the prenatal genetic testing of foetal chromosomal aneuploidies from Mother’s Blood. We have the credit of being the first centre in the Indian subcontinent to develop in-house Non-Invasive Prenatal Testing (NIPT) which is 99.9% sensiti...

Genetic Diagnosis (PGD)

PGD for Chromosomal Translocations: Preimplantation Genetic Diagnosis (PGD) – done on embryos created after IVF wherein the genetic diagnosis...

Pre-Implantation Genetic Screening (PGS)

24 chromosome PGS Pre-Implantation Genetic Screening (PGS) involves a process of screening of embryos in the course of In Vitro Fertilization (IVF). ...

  • cytogenetics

    Cytogenetics refers to the study of chromosome content in a cell. Argenomics has a fully equipped Cytogenetics lab with automated Karyotyping and FISH software. A complete Karyotype including structural chromosomal abnormalities and micro-deletions can be obtained using this facility. FISH is only performed on selected chromosomes. Cytogenetic studies can be done on a variety of samples like Peripheral blood, Amniotic fluid, CVS, and products of conception.

  • Hereditary Disease

    Targeted Mutation Screening  is a diagnostic tool completed through blood test that identifies the mutated gene or genes causing a genetic disease in your family. The identification of a gene mutations allows for further steps to be taken to prevent the passing on of the condition to future generations and may aid in the improvement of treatment of an affected individual. In most cases, after identifying the cause of genetic disease the couples can go with a Pre-Implantation Genetic Diagnosis (PGD) for Single Gene Disorders, a genetic test...


    Preconception genetic testing Pre-Implantation Genetic Screening (PGS) involves a process of screening of embryos in the course of In Vitro Fertilization (IVF). This helps to identify abnormalities in the chromosomes occurring due to aneuploidy. The main reason for recurrent IVF failures and in turn pregnancy losses is the higher risk of chromosomal errors that happ...