Maternity Based Testing

Non-Invasive Prenatal Test

This is the prenatal genetic testing of foetal chromosomal aneuploidies from Mother’s Blood. We have the credit of being the first centre in the Indian subcontinent to develop in-house Non-Invasive Prenatal Testing (NIPT) which is 99.9% sensitive to determine the chromosome mapping.

Non-invasive prenatal testing- uses cell-free foetal DNA from the plasma of pregnant women, offers tremendous potential as a screening tool for foetal chromosomal abnormalities. It is a simple blood test which requires blood from the expectant mother and studies the foetal DNA chromosomes for abnormalities like Down's Syndrome, Edward's Syndrome, Patau Syndrome and complete chromosomal mapping including micro-deletions.

Unlike amniocentesis (invasive procedure), NIPT carries no risk of miscarriages. Screening for foetal chromosomal abnormalities during pregnancy is an essential part of obstetrical care to reduce the burden of diseases. NIPT is a safe screening test which can be offered to all pregnant women and is not limited to the above indications.

  • Screening of full 23 pair chromosomes with micro-deletions.
  • Better than every other biochemical screening methods because it is 99% sensitive.
  • For screening with twin pregnancies, this method is more sensitive.
  • Along with a live twin, vanishing twin can also be differentiated.
  • The procedure involved here is non-invasive, risk-free and accurate.
  • This method makes it possible to also report foetal fraction
  • It is possible for chromosomal abnormalities to be diagnosed early using this method.
  • Prenatal diagnosis
  • By adopting this method invasive procedures such as CVS and amniocentesis can be avoided.
  • As the test can be done as early as during the first Target scan itself, it frees couples of anxieties.

Indications for NIPT:

  • When the mother is at an advanced age.
  • If the family has earlier history of conceiving an anomalous child.
  • In case of any USG findings.
  • In case, a positive 1st trimester screening has resulted.

Analysis of Aminotic Fluid

Amniocentesis (KT+FISH): It is a medical procedure used in diagnosis of chromosomal abnormalities and fetal infections  in which a small  amount of amniotic fluid, which contains fetal cells, is sampled from the amniotic sac surrounding a developing fetus, and the fetal DNA is examined for genetic abnormalities. The fluid is sent to genetics lab post collection. The greatest advantage of doing Amniocentesis at Argenomics is our RAPID FISH reporting time is 24- 48 hours , this itself reduces the anxiety in pregnant women

Indications:

•    USG anomalies
•    Strong markers for Down’s syndrome (unossified NB, hypoplastic NB)
•    For confirming +ve NIPT with Intermediate and High Risk
•    Biochemical screen positive
•    Previous baby with down’s or family history of any genetic disorder
•    Advanced maternal age (above 35years) and pregnancy.

One of the major reasons for the recurring pregnancy losses and IVF failures is a disorder occurring in the endometrium which mainly concerns abnormal gene expressions. Now using the procedure Endometrial Receptor Gene Assay (ERGA), it is possible to...

This is the prenatal genetic testing of foetal chromosomal aneuploidies from Mother’s Blood. We have the credit of being the first centre in the Indian subcontinent to develop in-house Non-Invasive Prenatal Testing (NIPT) which is 99.9% sensiti...

Pre-Implantation
Genetic Diagnosis (PGD)

PGD for Chromosomal Translocations: Preimplantation Genetic Diagnosis (PGD) – done on embryos created after IVF wherein the genetic diagnosis...

Pre-Implantation Genetic Screening (PGS)

24 chromosome PGS Pre-Implantation Genetic Screening (PGS) involves a process of screening of embryos in the course of In Vitro Fertilization (IVF). ...

  • cytogenetics

    Cytogenetics refers to the study of chromosome content in a cell. Argenomics has a fully equipped Cytogenetics lab with automated Karyotyping and FISH software. A complete Karyotype including structural chromosomal abnormalities and micro-deletions can be obtained using this facility. FISH is only performed on selected chromosomes. Cytogenetic studies can be done on a variety of samples like Peripheral blood, Amniotic fluid, CVS, and products of conception.

  • Hereditary Disease

    Targeted Mutation Screening  is a diagnostic tool completed through blood test that identifies the mutated gene or genes causing a genetic disease in your family. The identification of a gene mutations allows for further steps to be taken to prevent the passing on of the condition to future generations and may aid in the improvement of treatment of an affected individual. In most cases, after identifying the cause of genetic disease the couples can go with a Pre-Implantation Genetic Diagnosis (PGD) for Single Gene Disorders, a genetic test...

  • REPRODUCTIVE GENETICS

    Preconception genetic testing Pre-Implantation Genetic Screening (PGS) involves a process of screening of embryos in the course of In Vitro Fertilization (IVF). This helps to identify abnormalities in the chromosomes occurring due to aneuploidy. The main reason for recurrent IVF failures and in turn pregnancy losses is the higher risk of chromosomal errors that happ...